Low-dose developmental exposure to bisphenol A alters the femoral bone geometry in wistar rats

In utero and lactational exposure to the lowest BPA dose used in this study altered femoral geometry in both male and female offspring. This was observed at 25 μg BPA/kg bw/day, a dose lower than the Human Equivalent Dose (HED) applied by EFSA to set a temporary TDI (609 μg BPA/kg bw/day), and far lower than the No-Observed-Adverse-Effect-Level (NOAEL) (5000 μg BPA/kg bw/day) on which the US FDA TDI is based.