Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6308206 | Chemosphere | 2015 | 8 Pages |
Abstract
In this study we demonstrate that CPF (50 μM) induces redox imbalance altering the antioxidant defense system in breast cancer cells. Furthermore, we found that the main mechanism involved in the inhibition of cell proliferation induced by CPF is an increment of p-ERK1/2 levels mediated by H2O2 in breast cancer cells. As PD98059 could not abolish the increment of ROS induced by CPF, we concluded that ERK1/2 phosphorylation is subsequent to ROS production induced by CPF but not the inverse.
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Authors
Clara Ventura, Andrés Venturino, Noelia Miret, Andrea Randi, Elena Rivera, Mariel Núñez, Claudia Cocca,