Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6308394 | Chemosphere | 2015 | 4 Pages |
Abstract
Several studies have suggested that maternal exposure to Polychlorinated dibenzo-p-dioxins (PCDDs), poly-chlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (PCBs) may affect foetal growth and infant development. The aim of our study was to determine whether the childbearing-aged residents living near a chemical plant have a greater exposure risk. Concentrations of 17 PCDD/Fs congeners and 12 non-ortho and mono-ortho dioxin-like PCBs were measured using HRGC-HRMS in the blood of 30 non-occupational childbearing-aged women living near a chemical plant (Dagu) that had been producing chlorinated pesticides from 1958 to 2004. The factors that influenced the body burden were investigated based on responses to a questionnaire. Levels of PCDD/Fs + PCBs were in the range of 16.43-155.29 pg WHO 2005-TEQ gâ1 lipid. PCDDs and PCDFs contributed 56.72% and 34.44%, respectively, to the total TEQ value. Total WHO-TEQ was approximately tenfold higher in the participants living in the vicinity of the plant (distance: 1.52 ± 0.148 km) than in the groups living farther away (distance: 4.93 ± 1.124 km). A negative correlation between total WHO-TEQ and distance to Dagu was observed by multiple linear regression models. The data provide basic information for monitoring dioxin-like chemicals in the district and for the future study of the relationship between POPs and pregnancy outcomes.
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Authors
Chen Xi, Chen Jing-shan, Zhang Lei, Li Jing-guang, Yao Lena, Steven G. Self, Sun Xin, Tang Nai-jun,