| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6309488 | Chemosphere | 2014 | 8 Pages |
Abstract
All studied sulfonamides undergo photodegradation under UV-light exposure to a greater or lesser extent. The degradation products have no cytotoxic potential except sulfanilamide and have a slight impact on cell proliferation. All degradation products showed no antibacterial activity. Thus, UV-light exposure seems to represent an adequate method for inactivating sulfonamides with regard to their antimicrobial activity.
Keywords
SMZPBSpentafluorophenylSDZSulfamethoxypyridazineSMXSTZSMRRPMIPFPDMSOScyDimethylsulfoxideCytotoxicitySulfamethazineSulfathiazoleSulfadiazineSulfadimethoxineSulfamerazineSulfamethoxazoleSulfanilamideSulfachloropyridazineSulfonamidesPhotodegradationPhosphate buffered salineAntibacterial activitySDMRosewell Park Memorial Institutehigh performance liquid chromatographyHPLC
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Authors
Katrin Zessel, Siegrun Mohring, Gerd Hamscher, Manfred Kietzmann, Jessica Stahl,