Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6309977 | Chemosphere | 2014 | 6 Pages |
Abstract
Milk secretion being an important way of elimination of organochlorine pesticides (OCPs) poses a concern due to potential risk for breastfed infants. This study aims to provide a tool for assessing such risks to infants exposed to OCPs (through accumulation in the mother's body), using calculated individual margins of safety (MoS). Selected OCPs included; p,pâ²-DDT, p,pâ²-DDD, p,pâ²-DDE, β-HCH, γ-HCH and HCB which were analysed in 28 samples of maternal milk. The highest intakes were recorded for p,pâ²-DDE (at 2.90 μg kgâ1 bw dâ1) whilst the lowest was for γ-HCH, (at 0.019 μg kgâ1 bw dâ1). For the risk characterisation purposes MoSs were calculated for the compounds for which toxicological reference values (e.g. ADI, TDI) were adopted. The MoS for average âDDT concentrations was found to be relatively low (2.82) somewhat similar to that for HCB at 7.08, and for γ-HCH, the MoS was substantially higher at 263.1. This, however does not take into account the extremely high individual concentrations. Thus, it was decided to calculate estimated daily intake (EDI) values based on OCP levels in individual milk samples. MoS levels of <1 (meaning unacceptable risk) were noted both for HCB in one sample as well as for âDDT in 3 samples indicating likely threats to infant's health. The lowest MoS noted for γ-HCH equalled to 60.6, indicating that this compound was not a threat to the health of any of the breastfed infants from the study group.
Related Topics
Life Sciences
Environmental Science
Environmental Chemistry
Authors
A. Hernik, K. Góralczyk, P. StruciÅski, K. Czaja, W. Korcz, M. Minorczyk, M. Åyczewska, J.K. Ludwicki,