Insights into the structure of urea-like compounds as inhibitors of the juvenile hormone epoxide hydrolase (JHEH) of the tobacco hornworm Manduca sexta: Analysis of the binding modes and structure-activity relationships of the inhibitors by docking and Co

► SAR of urea-like compounds as inhibitors of JHEH of Manduca sexta is modeled. ► The orientation of the compounds inside JHEH active site was obtained by docking. ► CoMFA models identified the structural features relevant for the activity.