Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6312788 | Environment International | 2016 | 8 Pages |
Abstract
Perfluorinated chemicals (PFCs) have been widely used in a variety of products worldwide. Our previous study has documented a close association of higher serum level of perfluorooctane sulfonate (PFOS) with an increased carotid intima-media thickness (CIMT) in a cohort of adolescents and young adults. Herein, we further investigated the association of oxidative stress, circulating endothelial microparticles (EMPs) and platelet microparticles (PMPs) with PFCs and CIMT in humans. We recruited 848 subjects (12-30 years old) from a population-based sample to determine the relationship between serum levels of PFCs, EMPs (CD62E and CD31 +/CD42a â), PMPs (CD62P and CD31 +/CD42a +), and the urine levels of 8-hydroxydeoxyguanosine (8-OHdG) and CIMT. The results showed that CD31 +/CD42a â (endothelial apoptosis marker) and CD31 +/CD42a + (platelet apoptosis marker) increased significantly across quartiles of PFOS in multiple linear regression analysis. Furthermore, the elevation of CD31 +/CD42a â and CD31 +/CD42a + corresponded to the increase of the odds ratios of thicker CIMT (greater than 50th percentile) with higher serum PFOS concentration (greater than 50%) (OR = 2.86, 95% C.I. = 1.69-4.84, P < 0.001) in logistic regression models. There was no association between PFC concentration and 8-OHdG. In conclusion, we found the positive association between PFOS and CIMT that was more evident when serum levels of EMPs (CD31 +/CD42a â) and PMPs (CD31 +/CD42a +) were elevated. Further studies are warranted to investigate the causal inference of PFOS exposure on endothelial cell damage and atherosclerosis.
Keywords
Carotid intima-media thickness (cIMT)HDL-CCIMTNTDPMPsNHANEShs-CRPPFCs8-OHdGLDL-CCD31New Taiwan DollarPFNAPFOSPFOAPerfluorinated chemicals (PFCs)Systolic and diastolic blood pressureregulated on activation, normal T cells expressed and secreted8-hydroxydeoxyguanosinehomeostasis model assessment of insulin resistancePerfluorononanoic acidPerfluoroundecanoic acidNational Health and Nutrition Examination SurveyEMPsMicroparticlesendothelial microparticlesPerfluorooctane sulfonatePerfluorooctane sulfonate (PFOS)body mass indexBMICarotid intima-media thicknesshigh-density lipoprotein cholesterolRANTESPerfluorinated chemicalsPlatelet microparticlesHOMAPerfluorooctanoic acidhigh sensitivity C-reactive proteinLow-density lipoprotein cholesterol
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Authors
Chien-Yu Lin, Pau-Chung Chen, Shyh-Chyi Lo, Pao-Ling Torng, Fung-Chang Sung, Ta-Chen Su,