Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6315730 | Environmental Pollution | 2016 | 6 Pages |
Abstract
To investigate the risk of hyperuricemia in relation to Perfluoroalkyl substances (PFASs) in children from Taiwan, 225 Taiwanese children aged 12-15 years were recruited from 2009 to 2010. Linear and logistic regression models were employed to examine the influence of PFASs on serum uric acid levels. Findings revealed that eight of ten PFASs analyses were detected in >94% of the participants' serum samples. Multivariate linear regression models revealed that perfluorooctanic acid (PFOA) was positively associated with serum uric acid levels (β = 0.1463, p < 0.05). Of all the PFASs analyses, only PFOA showed a significant effect on elevated levels of hyperuricemia (aOR = 2.16, 95%CI: 1.29-3.61). When stratified by gender, the association between serum PFOA and uric acid levels was only evident among boys (aOR = 2.76, 95%CI: 1.37-5.56). In conclusion, PFOA was found to be associated with elevated serum levels of uric acid in Taiwanese children, especially boys. Further research is needed to elucidate these links.
Keywords
PFHxAPFHpAperfluorododecanoic acidPerfluorotetradecanoic acidPerfluoroheptanoic acidPolyfluoroalkyl substancesPFDoAPFDAPFNAperfluorohexane sulfonateGBCaPFBSPFHxSIQRPFOAPFOSPerfluorobutane sulfonateORSPFASs95%CIperfluorodecanoic acidPerfluorononanoic acidUric acidPerfluorooctane sulfonate95% confidence intervalsinterquartile rangePerfluoroalkyl substancesodds ratioHyperuricemiaChildren
Related Topics
Life Sciences
Environmental Science
Environmental Chemistry
Authors
Xiao-Di Qin, Zhengmin Qian, Michael G. Vaughn, Jin Huang, Patrick Ward, Xiao-Wen Zeng, Yang Zhou, Yu Zhu, Ping Yuan, Meng Li, Zhipeng Bai, Gunther Paul, Yuan-Tao Hao, Wen Chen, Pau-Chung Chen, Guang-Hui Dong, Yungling Leo Lee,