Pro-inflammatory effects and oxidative stress in lung macrophages and epithelial cells induced by ambient particulate matter

Article ID	Journal	Published Year	Pages	File Type
6318431	Environmental Pollution	2013	11 Pages	PDF

Abstract

âº The study compares the toxicological effects of different source-related particles with regard to their chemical composition. âº The chemical characterization of the coarse particles revealed clear differences in elemental, TC and PAH composition. âº Equal mass concentrations of urban traffic and rural PM caused different toxicological responses. âº The observations confirm the hypothesis that particle composition, as well as origin, influence the PM-induced toxicity.

Keywords

GRC GSSG RNS NF-kB GPX CAT FBS UFP LVS CyP RAW264.7 A549 PBS PAH VOC NADP+/NADPH GSH ROS Arsenic Aluminum enzyme linked immunosorbent assay Iron Toxicological effects interleukin COPD Chronic obstructive pulmonary disease Chemical composition Volatile organic compounds ELISA Oxidative stress tumor necrosis factor-α particulate matter Ultrafine particulate matter SOD Sodium Lead fetal bovine serum Cytotoxicity Superoxide-dismutase cytochrome TNF-α Nuclear factor-kappa B Phosphate buffered saline Zinc SEM Copper Manganese Magnesium Scanning electron microscopy Nickel nicotinamide adenine dinucleotide phosphate Polycyclic aromatic hydrocarbons Vanadium Inflammatory response Potassium Catalase Cadmium Chromium total carbon Calcium Glutathione glutathione disulphide glutathione reductase glutathione peroxidase reactive nitrogen species Reactive oxygen species