Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
63193 | Journal of Catalysis | 2007 | 8 Pages |
Abstract
Up to now, the anti-inflammatory agent nabumetone has been synthesized by a two-step process involving either a Heck reaction between 6-bromo-2-methoxynaphthalene and methyl vinyl ketone or a condensation between 6-methoxy-2 naphthaldehyde and acetone to give an intermediate that is separated, purified, and hydrogenated in a second and separate process to give the final product, while producing a large amount of waste products. Here we report a residue-free catalytic process for the production of nabumetone with ⩾98%⩾98% yield and 100% selectivity achieved through a cascade reaction system involving a multifunctional base/acid/hydrogenation catalyst based on nanocrystalline (∼3 nm) MgO.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Maria Jose Climent, Avelino Corma, Sara Iborra, Maria Mifsud,