Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
63232 | Journal of Catalysis | 2006 | 8 Pages |
Abstract
A highly effective asymmetric heterogeneous catalytic hydrogenation of isophorone (3,5,5-trimethyl-2-cyclohexenone) by proline-modified base-supported Pd catalysts is described. Effective combination of enhanced proline adsorption and secondary kinetic resolution resulted in very high enantioselectivities (ee up to 99%). Using (S)- and (R)-proline enantiomers as chiral auxiliaries, both enantiomers of the product were obtained with excellent optical yields.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Shilpa C. Mhadgut, Marianna Török, Joseph Esquibel, Béla Török,