Maternal smoking during pregnancy, polymorphic CYP1A1 and GSTM1, and lung-function measures in urban family children

Article ID	Journal	Published Year	Pages	File Type
6353342	Environmental Research	2011	7 Pages	PDF

Abstract

âº We examined prenatal tobacco exposure, xenometabolic genes, and child lung function in a low-income pediatric sample. âº Overall, maternal smoking during pregnancy was associated with significant reductions in key lung-function measures. âº Greater lung-function reductions were observed in children of smoking mothers who possessed the polymorphic CYP1A1*2A and GSTM1 deletion.

Keywords

FEV1 GSTM1 FVC CYP1A1 glutathione S-transferase mu 1 FEF25–75 standard deviation Forced expiratory volume PCR–RFLP cytochrome P450 1A1 maternal smoking forced vital capacity Lung function polymerase chain reaction–restriction fragment length polymorphism Metabolic genes