Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
636483 | Journal of Membrane Science | 2010 | 7 Pages |
Abstract
Electrospinning of polylactide-polyglycolide (PLGA)/collagen in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) to fabricate a biomimetic nanofibrous extracellular membranes for wound dressing and tissue engineering was investigated. The morphology of as-spun PLGA/collagen nanofibers was examined by scanning electron microscopy. The average diameter of electrospun nanofibers was 250Â nm (range of 150-650Â nm). Degradation rate of PLGA/collagen nanofibrous membranes, cytocompatibility and cellular responses to membranes, cell and nanofibers interactions, and open wound healing in rats were studied. It was found that nanofibrous membranes made of PLGA/collagen were functionally active in responses in human fibroblasts, and were very effective as wound-healing accelerators in early-stage wound healing. The empirical results in this study indicate that electrospun PLGA/collagen nanofibers may be a good candidate as a wound dressing for skin regeneration.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Filtration and Separation
Authors
Shih-Jung Liu, Yi-Chuan Kau, Chi-Yin Chou, Jan-Kan Chen, Ren-Chin Wu, Wen-Ling Yeh,