Article ID Journal Published Year Pages File Type
637569 Journal of Membrane Science 2008 7 Pages PDF
Abstract

An issue identified during filtration of mAb drug substance is Polysorbate-20 absorption by polyethersulfone filter membranes. Experiments determined that both polyvinylidene fluoride filter membranes and polyethersulfone filter membranes bind Polysorbate-20. Saturation point, bound surfactant amount per square cm of membrane, and non-specific binding mechanisms are described in this report. An appropriate approach for preventing Polysorbate-20 loss in drug substance and drug product is presented.

Related Topics
Physical Sciences and Engineering Chemical Engineering Filtration and Separation
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