Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
637569 | Journal of Membrane Science | 2008 | 7 Pages |
Abstract
An issue identified during filtration of mAb drug substance is Polysorbate-20 absorption by polyethersulfone filter membranes. Experiments determined that both polyvinylidene fluoride filter membranes and polyethersulfone filter membranes bind Polysorbate-20. Saturation point, bound surfactant amount per square cm of membrane, and non-specific binding mechanisms are described in this report. An appropriate approach for preventing Polysorbate-20 loss in drug substance and drug product is presented.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Filtration and Separation
Authors
Joe X. Zhou, Jinshu Qiu, Ge Jiang, Chengfeng Zhou, Neil Bingham, Helena Yeung, Bryan Dransart, Manpreet-Vick Wadhwa, Tim Tressel,