| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6387835 | Marine Environmental Research | 2014 | 5 Pages |
Abstract
The aim of this study was to characterize the responsiveness of CYP1A and ABC transport proteins in European Sea bass (Dicentrarchus labrax) waterborne exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (46Â pg/L) for 24Â h and 7 days. Genes modulation (abcb1, abcc1-2, cyp1a), EROD activity were investigated in liver and 2,3,7,8-TCDD bioconcentration in liver and muscle. TCDD induced significantly cyp1a gene expression and EROD activity at 24Â h and 7Â d. A significant up-regulation of abcb1 was also observed but only after 7 days. No modulation of abcc1 and abcc2 genes was observed. Waterborne TCDD exposure was able to induce CYP1A and abcb1 encoding for P-glycoprotein in juvenile of European sea bass.
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Earth and Planetary Sciences
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Authors
Camilla Della Torre, Michela Mariottini, Maria Luisa Vannuccini, Anna Trisciani, Davide Marchi, Ilaria Corsi,