Use of bipolar membrane electrodialysis (BME) in purification of l-ascorbyl-2-monophosphate

As a stable substitute of Vitamin C, l-ascorbyl-2-monophosphate (AMP) has many applications, such as skin protecting, skin treatment, and fish diary feed. For decades, several methods were developed for the production of AMP. However, no purification process with high yield, short route and limited waste production, was developed. As an environment friendly separation method, electrodialysis was introduced into the production of l-ascorbyl-2-monophosphate for the first time in this work. By achieving a ‘one-step’ removal of impurity ions, deacetalization of IAMP and recovery of KOH, the constant-voltage BME process provided an efficient and environment friendly purification method. The AMP-acid was obtained, and could further produce a series of AMP salts. In addition, the influence of potential difference per three-compartment unit was studies. Process under 6 V/Unit and 5.3 V/Unit achieved both high separation efficiency and low energy consumption, and the combined use of 5.3 V/Unit and 6 V/Unit in different stages was anticipated to be the optimum process with optimum energy consumption.

► BME were applied in purification of l-ascorbyl-2-monophosphate (AMP). ► AMP were purified in a single-step process with high molar yield by using BME. ► Alkali produced in BME process can be reused to save cost and reduce. ► pollution. ► The BME process produced limited waste water which is environmental friendly. ► Potential difference of the BME process was optimized for lower energy cost.