| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6444593 | Journal of Asian Earth Sciences | 2013 | 4 Pages |
Abstract
In summary, we hypothesize that low concentration (0.5-1 μM) of arsenic-induced E2F1-Aurora-A signaling pathway results in aberrant chromosome distribution during cell mitosis, the abnormal mitotic cells proceed to cancer cells only after acquiring additional tumorigenic factors. Our studies suggest that inhibition of low concentration of arsenic induced Aurora-A expression may provide a new theraputical strategy for the prevention and treatment of arsenic-related cancers.
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Authors
Chin-Han Wu, Ya-Shih Tseng, Chao-Chun Yang, Yu-Ting Kao, Hamm-Ming Sheu, Hsiao-Sheng Liu,