Article ID Journal Published Year Pages File Type
6468739 Comptes Rendus Chimie 2017 6 Pages PDF
Abstract

Bone grafts are used in a wide array of clinical settings to augment bone repair and regeneration. This article reports a new method for the elaboration of a hybrid biomaterial in the form of sponge based on collagen gel, CaCO3 from recycled Rapana thomasiana seashell, and Na2HPO4·2H2O. Practically, collagen acts as a matrix through which calcium and phosphate ions are diffusing during in situ hydroxyapatite synthesis. The organic-inorganic interactions among biomaterial components have been studied by infrared spectroscopy, and the surface morphology was investigated by scanning electron microscopy technique. Moreover, the developed biomaterials were studied for in vitro biocompatibility with MG63 human osteoblasts. The results obtained demonstrated that the developed hybrid material does not exhibit a significant cytotoxicity and supports cell proliferation. Consequently, it holds great promise for applications in bone tissue engineering.

Related Topics
Physical Sciences and Engineering Chemical Engineering Chemical Engineering (General)
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