Electrochemical mediatorless detection of norepinephrine based on MoO3 nanowires

•Controlled synthesis and growth evolution of 1D MoO3 NWs is systematically studied.•The MoO3 NWs/GCE exhibits magnificent response time of 2 s towards electrochemical detection of norepinephrine.•The MoO3 NWs/GCE shows a promising diffusion constant (D) value of 3.34 × 10−5 cm2s−1 along with a heterogeneous rate constant (k) of 8.03 × 10−4 cm/s.•The MoO3 NWs/GCE possesses high stability, reproducibility, and selectivity.

Achieving direct electron transfer between a biomolecule and modified electrodes is paramount for fabricating advanced biosensor devices. In this report, 1-dimensional (1D) MoO3 nanowires (NWs) were synthesized in a systematic growth evolution study. These MoO3 NWs, with the glassy carbon electrodes (GCEs), were further used as a mediatorless biosensor electrode for the detection of norepinephrine (NE) by cyclic voltammetry and chronoamperometry techniques. The MoO3 NWs/GCE had a magnificent response time of 2 s in the electrochemical detection of NE, with a detection limit of 0.11 μM. This excellent bio-electrochemical performance is attributed to its high catalytic activity and 1D microstructure, providing a path for electron transport and increasing their sensitivity. The MoO3 NWs/GCE also had a promising diffusion constant (D) value of 3.34 × 10−5 cm2/s and a heterogeneous rate constant (k) of 8.03 × 10−4 cm/s. The modified electrode possessed high stability, reproducibility, and selectivity.

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