Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6482112 | Vaccine | 2010 | 8 Pages |
Abstract
In this study, we explored immune responses after intramuscular co-administration of the HIV-1 gp160 Env gene-expressing adenovirus (Ad) vector and modified vaccinia virus Ankara (MVA) vector in a mouse model. Surprisingly, the simultaneous vaccination of the two vaccines, either as a mixture or separately, suppressed responses, when compared with the administration of each vaccine separately. Ad vaccine or MVA vaccine, co-administered with a mock MVA or mock Ad vector, also resulted in suppressing HIV-specific effector T-cell responses, and a part of antigen-specific memory T-cell responses. In an in vitro experiment, the two vectors infected individual cells and MVA suppressed the transgene expression produced by the adenovirus vector. This viral interference may involve soluble factor(s), secreted by virus-infected cells. Our study may help in designing a vaccination regimen and in investigating viral interference.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Sayaka Yashima, Shinji Yoshizaki, Kaori Shinoda, Atsushi Yoshida, Asami Kondo, Hiroyuki Mizuguchi, Akihide Ryo, Kenji Okuda, Masaru Shimada,