Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6528641 | Journal of CO2 Utilization | 2018 | 7 Pages |
Abstract
In this work, a supercritical CO2 based one-step continuous process, named Supercritical Assisted Liposome formation (SuperLip), was used for the production of liposomes to deliver ophthalmic antibiotics, such as ampicillin and ofloxacin. Micrometric and sub-micrometric liposomes with mean diameters in the range from 280â¯Â±â¯104â¯nm to 1.76â¯Â±â¯0.79â¯Î¼m were successfully produced using drug concentrations in the range from 1% to 6% w/w and water to lipid ratios from 1.7â¯mg/g to 25â¯mg/g. Encapsulation efficiencies up to 97% and 99% were obtained for ofloxacin and ampicillin respectively. Storage stability and drug release kinetics of produced liposomes were also studied. Liposomes were stable for at least 3 months, with negligible drug leakage during storage time. At 37â¯Â°C ofloxacin and ampicillin were released in a controlled manner within 3 and 4â¯h respectively.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
R. Campardelli, P. Trucillo, E. Reverchon,