Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
654584 | International Communications in Heat and Mass Transfer | 2009 | 5 Pages |
Abstract
This paper investigates the effect of degradation of proteins transported by means of slow axonal transport (due to enzyme-mediated breakdown of proteins) on the speed of the bell-shaped wave of protein concentration propagating toward the synapse of the axon. Another issue investigated in this paper is the effect of protein degradation on the traffic jam caused by a decay of microtubule tracks at a certain location in the axon. The decay of microtubule tracks may be caused by misregulation of microtubule-associated proteins resulting from an imbalance in intracellular signaling or by mutations of these proteins. Axonal swellings caused by such traffic jams hinder axonal transport; they are a likely cause of various neurodegenerative diseases, including Alzheimer's and Parkinson's diseases and the Down syndrome.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Fluid Flow and Transfer Processes
Authors
A.V. Kuznetsov, A.A. Avramenko, D.G. Blinov,