| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 65522 | Journal of Molecular Catalysis A: Chemical | 2014 | 6 Pages |
•Al grafted MCM-41 showed potential of direct N-alkylation of amines with alcohols.•Solvent free and base/promotor free N-alkylation method was established.•Effect of catalyst acidity, reaction conditions and substrates nature were studied.•Benzylic, primary and secondary alcohols were activated for N-alkylation reaction.•Deactivated amine substrates could also be alkylated by alcohols.
The catalytic activity of Al grafted MCM-41 (Al-MS) was explored for solvent free acid catalysed direct N-alkylation of amines using alcohols as green alkylating agent to establish a clean method for synthesis of N-alkylated amines. The study revealed that acidity of Al-MS catalyst, reaction conditions and substrate's (amines and alcohols) nature are important factors influencing the N-alkylation reaction. The Al grafted MCM-41 with Si/Al molar ratio of 5 showed excellent activity for N-alkylation of amines with alcohols. The reusability of spent catalyst regenerated by simple washing with acetone was demonstrated for subsequent four reaction cycles.
Graphical abstractThe Al grafted MCM-41 (Si/Al = 5) showed good to excellent activity in solvent free acid catalysed direct N-alkylation of amines with alcohols giving selective conversion to N-alkylated amines.Figure optionsDownload full-size imageDownload high-quality image (141 K)Download as PowerPoint slide
