| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6552536 | Forensic Science International | 2014 | 5 Pages |
Abstract
A massive lethal overdose with beta-metildigoxin in a 36-week-old infant is presented. Determination of beta-metildigoxin and its metabolites digoxin, digoxigenin and digoxigenin-monodigitoxosid is achieved by a liquid chromatographic mass spectrometric (LC-MS/MS) method. Measured concentrations for beta-metildigoxin and digoxin in peripheral blood were 40.2Â ng/ml and 25.6Â ng/ml, respectively. Tissue distribution showed highest concentrations in kidney tissue and gastric content. The metabolite digoxigenin-monodigitoxosid could be detected in heart blood, duodenal content, gastric content and fat tissue while the metabolite digoxigenin could only be detected in gastric content since the drug was given by a stomach tube.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Cornelius Hess, Christopher Brockmann, Elke Doberentz, Burkhard Madea, Frank Musshoff,