Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6553232 | Forensic Science International: Genetics | 2018 | 21 Pages |
Abstract
Current models for single source and mixture samples, and probabilistic genotyping software based on them used for analysing STR electropherogram data, assume simple probability distributions, such as the gamma distribution, to model the allelic peak height variability given the initial amount of DNA prior to PCR amplification. Here we illustrate how amplicon number distributions, for a model of the process of sample DNA collection and PCR amplification, may be efficiently computed by evaluating probability generating functions using discrete Fourier transforms.
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Authors
Robert G. Cowell,