| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 65544 | Journal of Molecular Catalysis A: Chemical | 2014 | 12 Pages |
•Multicomponent reactions are powerful tools in modern drug discovery processes.•Ce-MCM-41 has large specific surface area and good textural properties.•Xanthenones have wide range of biological and therapeutic properties.•Eco-compatibility and solvent-free protocols are added advantages of the reaction.
We report here, three-component condensation reaction of naphthols, aldehydes and 1,3-dicarbonyl compounds catalyzed by Ce-MCM-41 under solvent-free conditions. Several advantages can be perceived using this eco-friendly protocol such as, a green and cost-effective procedure with excellent yield, shorter reaction time, simpler work-up, recovery and reusability of solid acid heterogeneous catalyst and tolerance towards a wide range of functional groups. We also report here the anti-microbial activities of the new compounds. Particularly, it was found that the new compounds have shown promising effect on Pseudomonal infections.
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