Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6555559 | Pathology | 2018 | 12 Pages |
Abstract
Recent molecular analyses of some SCSTs has led to the discovery of novel molecular events, which may have important diagnostic, prognostic and therapeutic implications. The salient pathological features, management issues and recently described genetic aberrations in adult and juvenile granulosa cell tumours as well as Sertoli-Leydig cell tumours are discussed in this review, with particular emphasis on the clinical significance of FOXL2 and DICER1 mutations. An in-depth understanding of the molecular pathogenesis underlying SCSTs may aid in improving tumour classification and disease prognostication and also potentially lead to the discovery of more effective treatment strategies.
Related Topics
Health Sciences
Medicine and Dentistry
Forensic Medicine
Authors
Diana Lim, Esther Oliva,