Protocole Esteban : une Étude transversale de santé sur l'environnement, la biosurveillance, l'activité physique et la nutrition (2014-2016)

As part of the French human biomonitoring program, a cross-sectional survey, called Esteban, based on a representative sample of the French population (6-74 years old) is ongoing. Its aims are: (i) to estimate exposure biomarkers levels of various chemical agents having an impact presumed and/or observed on the health, and establish reference values; (ii) describe food consumptions, physical activity, sedentary and nutritional state; (iii) estimate prevalence of chronic diseases, asthma, atopy and allergic diseases. Each participant answers a “questionnaire survey”, and undergoes “a biological and clinical exam”, including a range of measures (anthropometric, blood pressure, functional respiratory investigations for the adults) and a collection of biological samples (blood, urine and hair). A hundred of chemicals belonging to biomarkers' families (pesticides, metals, phthalates, bisphenols, polycyclic aromatic hydrocarbons…), of nutritional state and chronic diseases, will be analyzed in centralized laboratories. Esteban included 1104 children and 2503 adults. Participation rates were between 39% and 54% for children and between 43% and 57% for adults. Esteban will allow following the evolution of indicators in ENNS (2006-2007), it will then allow comparison to other national and international initiatives, and bring information for health policies and regulations aiming to reduce environmental exposures to chemicals.