Palladium-catalyzed arylation of aryl sulfonamides with cyclohexanones

•A Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations of cyclohexanones with aryl sulfonamides is described.•Cyclohexanones acted as aryl sources via dehydrogenation and tautomerization.•Various N-aryl sulfonamides were selectively obtained in good yield using molecular oxygen as oxidant.•Functional groups were well tolerated under the optimized reaction conditions.

Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations have been developed for the arylation of aryl sulfonamides with cyclohexanones. Various N-aryl sulfonamides were selectively obtained in good yields using molecular oxygen as oxidant. The reaction tolerated a wide range of functionalities.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (88 K)Download as PowerPoint slide