Magnetic Fe3O4 nanoparticles: Efficient and recoverable nanocatalyst for the synthesis of polyhydroquinolines and Hantzsch 1,4-dihydropyridines under solvent-free conditions

•Fe3O4 nanoparticles used as a magnetically separable and inexpensive catalyst.•Catalyst applied for preparation of 1,4-dihydropyridines and polyhydroquinolines.•Fe3O4 nanoparticles show good catalytic activity.•Fe3O4 nanoparticles are a recyclable and eco-benign catalyst for this transformation.

A green approach for efficient and rapid synthesis of biologically active substituted Hantzsch 1,4-dihydropyridine and polyhydroquinoline derivatives using magnetic Fe3O4 nanoparticles (Fe3O4 MNPs) as a recyclable catalyst under solvent-free conditions was reported. The catalyst was characterized by FT-IR, XRD, and TEM analysis. Compared to the classical reactions, this method consistently has the advantages of short reaction times, little catalyst loading, high yields, easy magnetic separation and reusability of the catalyst.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (262 K)Download as PowerPoint slide