| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 65784 | Journal of Molecular Catalysis A: Chemical | 2013 | 7 Pages |
•New chiral iminopyridines were obtained from pyridyl aldehydes or ketones.•New chiral iminopyridines were obtained from a variety of chiral amines.•New chiral iminopyridines were assessed in the enantioselective Henry reaction.•1-(2-Methoxyphenyl)-2-nitroethanol was formed with enantioselectivities up to 82% ee.
Chiral iminopyridines obtained by reaction between a variety of chiral amines and pyridyl aldehydes or ketones were assessed as catalysts in the enantioselective Henry reaction between nitromethane and 2-methoxybenzaldehyde in the presence of copper(II) acetate. 1-(2-Methoxyphenyl)-2-nitroethanol was obtained in moderate yields and good enantioselectivities (up to 82% ee) under straightforward experimental conditions without the need for air or moisture exclusion. The best enantioselectivity (82% ee) was obtained by an iminopyridine based on a camphane skeleton.
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