| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6590211 | Chemical Engineering Science | 2015 | 9 Pages |
Abstract
Using polymeric surfaces is a novel way to control crystallization. However, the mechanism is still ambiguous. In the present study, chitosan (CS) films that were doped with different molecules were employed to investigate the impact of surface chemistry on the heterogeneous crystallization behavior of acetaminophen (APAP). Crystal growth rate and crystallization kinetic measurements of APAP on various substrates were performed. Fourier transform infrared spectroscopy was used to probe intermolecular interactions between APAP and CS films. The results were interpreted with the aid of molecular simulations. It was found that substrates with more hydrogen bonding groups that could interact with APAP promoted its crystallization.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Hsinyun Hsu, Oluwamayowa O. Adigun, Lynne S. Taylor, Sohail Murad, Michael T. Harris,