Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
659051 | International Journal of Heat and Mass Transfer | 2012 | 10 Pages |
Abstract
Detailed numerical simulations are performed for oxygen transfer around and within a circular scaffold for animal cell culture. The oxygen concentration distribution, minimum oxygen concentration within the scaffold and its corresponding location, as well as the Sherwood number are presented at different Darcy numbers, Reynolds numbers and Damkohler numbers. It is found that if the Reynolds number is increased from 1 to 30, the Sherwood number increases 1 time for a Darcy number of 5Â ÃÂ 10â6 while 34 times for a Darcy number of 5Â ÃÂ 10â4. The location of the minimum oxygen concentration is close to the centre of the scaffold when the Darcy number is smaller than about 5Â ÃÂ 10â5 or the Reynolds number is smaller than about 1, especially for the Damkohler number larger than O(10). The present study may provide useful guidance on design of the bioreactor with scaffold as well as choosing optimal operating parameters.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Fluid Flow and Transfer Processes
Authors
Peng Yu,