| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6591723 | Chemical Engineering Science | 2013 | 9 Pages |
Abstract
⺠A synthetic biology approach to vaccine design is reported. ⺠A virus-like particle capsomere is engineered for antigen modularization. ⺠Modular capsomeres were synthesized in Escherichia coli with high soluble yield. ⺠45 M2e modules were integrated into a single capsomere across three sites. ⺠Modularization of M2e peptide into a capsomere resulted in high immunogenicity.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Nani Wibowo, Yap P. Chuan, Linda H.L. Lua, Anton P.J. Middelberg,