Article ID Journal Published Year Pages File Type
6591742 Chemical Engineering Science 2013 6 Pages PDF
Abstract
► We perform specific genetic alterations to improve malonyl-CoA availability in Escherichia coli. ► Genetic interventions predicted by OptForce increase carbon flux through malonyl-CoA. ► We improve titers of plant natural product, resveratrol by ∼60%. ► We find optimal temperature for this fermentation along with the over-expressions.
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Related Topics
Physical Sciences and Engineering Chemical Engineering Chemical Engineering (General)
Preview
Redirecting carbon flux into malonyl-CoA to improve resveratrol titers: Proof of concept for genetic interventions predicted by OptForce computational framework
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