Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6591868 | Chemical Engineering Science | 2013 | 13 Pages |
Abstract
Furthermore, the results from above analyses (MBA, MFA, EFM and EPs) support following conclusions: the respiratory quotient value in mammalian cell culture generally should be near one; several potential metabolic bottlenecks (pyruvate to acetyl-CoA, cytosol NADH translocation into mitochondrion, glutamate dehydrogenation into TCA) may control and regulate cellular metabolism. These results will benefit the future study of dynamic modeling for process monitoring and control.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Hongxing Niu, Zakaria Amribt, Patrick Fickers, Wensong Tan, Philippe Bogaerts,