Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6594611 | Comptes Rendus Chimie | 2010 | 7 Pages |
Abstract
Metal complexes bearing phosphine ligands are attracting increasing attention for their applications in medicinal chemistry. In particular, organometallic ruthenium-phosphine complexes have been found to exhibit promising antitumour activity. The synthesis, anticancer activity and reactivity of a novel bis-phosphine complex, [Ru(η6-cymene)(PPh2(o-C6H4O)-κ2-P,O)(pta)]Cl (pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1.]decane), is presented. The complex appears to exhibit its anticancer effect via a different mechanism to other ruthenium-arene pta complexes with labile co-ligands.
Related Topics
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Chemical Engineering
Chemical Engineering (General)
Authors
Anna K. Renfrew, Alexander E. Egger, Rosario Scopelliti, Christian G. Hartinger, Paul J. Dyson,