Article ID Journal Published Year Pages File Type
65965 Journal of Molecular Catalysis A: Chemical 2013 9 Pages PDF
Abstract

A simple and environmentally friendly one-pot three components methodology has been commented for the Biginelli condensation of different substituted aldehydes with ethyl acetoacetate and urea to afford the corresponding 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions. H5PW10V2O40/Pip-SBA-15 was used as a non-toxic, inexpensive, and easily available organic–inorganic hybrid material as the catalyst. Utilization of easy reaction condition and simple work-up makes this methodology as an interesting option for the economic synthesis of dihydropyrimidinones.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (199 K)Download as PowerPoint slideHighlights► Modification of SBA-15 with piperazine to avoid leaching of the heteropolyacid. ► An environmentally friendly protocol to afford dihydropyrimidinones. ► SBA/Pip/H5PW10V2O40 as a new organic–inorganic hybrid material. ► Piperazine behaved as the best among various organic linkers.

Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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