Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
65965 | Journal of Molecular Catalysis A: Chemical | 2013 | 9 Pages |
A simple and environmentally friendly one-pot three components methodology has been commented for the Biginelli condensation of different substituted aldehydes with ethyl acetoacetate and urea to afford the corresponding 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions. H5PW10V2O40/Pip-SBA-15 was used as a non-toxic, inexpensive, and easily available organic–inorganic hybrid material as the catalyst. Utilization of easy reaction condition and simple work-up makes this methodology as an interesting option for the economic synthesis of dihydropyrimidinones.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (199 K)Download as PowerPoint slideHighlights► Modification of SBA-15 with piperazine to avoid leaching of the heteropolyacid. ► An environmentally friendly protocol to afford dihydropyrimidinones. ► SBA/Pip/H5PW10V2O40 as a new organic–inorganic hybrid material. ► Piperazine behaved as the best among various organic linkers.