Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6597604 | Dyes and Pigments | 2018 | 13 Pages |
Abstract
The imidazole derivative 4-(4,5-diphenyl-1H-imidazol-2-yl)-N,N-dimethylaniline (probe 1) formed a highly coloured and non-emissive 1:1 stoichiometry complex with Cu(II) in water-acetonitrile 1:1 (v/v) solutions. Among all the amino acids (Lys, Val, Gln, Leu, His, Thr, Trp, Gly, Phe, Arg, Ile, Met, Ser, Ala, Pro, Tyr, Gly, Asn, Asp, Glu, Cys and Hcy) and tripeptides (GSH) tested, only GSH induced the bleaching of the 1·Cu(II) solution together with a marked emission enhancement at 411â¯nm (excitation at 320â¯nm). These chromo-fluorogenic changes were ascribed to a selective GSH-induced demetallation of the 1·Cu(II) complex that resulted in a recovery of the spectroscopic features of probe 1. In addition to the remarkable selectivity of 1·Cu(II) complex toward GSH a competitive limit of detection as low as 2â¯Î¼M was determined using fluorescence measurements.
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Authors
Hazem Essam Okda, Sameh El Sayed, Rosa C.M. Ferreira, Susana P.G. Costa, Manuela M. Raposo, Ramón MartÃnez-Máñez, Félix Sancenón,