Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6607832 | Electrochimica Acta | 2016 | 29 Pages |
Abstract
An electrochemical study of methyldopa (MD), dopamine (DA) and adrenaline (AD) catecholamines was conducted using cyclic (CV) and square wave voltammetry (SWV). The pH-dependant electrochemical behavior of catecholamines was studied for the first time on fluorine doped tin oxide electrodes (FTO). The CV scan rate study showed the charge transfer process was diffusion controlled. Besides, electrochemical parameters such as diffusion coefficient, charge transfer coefficient and heterogeneous charge transfer rate constant were determined. The number of transferred electrons was 2. Furthermore, a method is proposed to determine MD in pharmaceutical preparations by SWV. Two linear ranges between 2.0·10â6 and 30.0 ·10â6 mol Lâ1 and 30.0·10â6 and 60.0·10â6 mol Lâ1 were found, with a limit of detection of 0.15·10â6 and 2.9·10â6 mol Lâ1, respectively. The method, displays good sensitivity and stability. This technique can be employed in clinical analysis, quality control and routine determination of drugs in pharmaceutical formulations.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
C. RamÃrez, M.A. del Valle, M. Isaacs, F. Armijo,