Unique versatility of Amberlyst 15. An acid and solvent-free paradigm towards synthesis of bis(heterocyclyl)methane derivatives

Bis(heterocyclyl)methanes, key intermediates for a variety of chemical, biochemical and material science relevant targets, have been obtained in a synthetically useful manner using Amberlyst 15 ion-exchange resin. This method promises versatility, cost-effectiveness, and efficiency.

Graphical abstractBis(heterocyclyl)methanes, key intermediates for a variety of chemical, biochemical and material science relevant targets, have been obtained in a synthetically useful manner using Amberlyst 15 ion-exchange resin. This method promises versatility, cost-effectiveness, and efficiency.Figure optionsDownload full-size imageDownload high-quality image (104 K)Download as PowerPoint slideHighlights► Bis(heterocyclyl)methanes have been synthesized in good yields using Amberlyst 15 as catalyst. ► This catalytic approach provides synthetic flexibility as various heterocycles have been prepared. ► It employs recyclable catalyst of industrial and environmental significance. ► The reaction is run without any solvent medium.