Cellulose sulfuric acid catalyzed multicomponent reaction for efficient synthesis of 1,4-dihydropyridines via unsymmetrical Hantzsch reaction in aqueous media

C5-unsubstituted 1,4-dihydropyridines were obtained in good to excellent yields by proceeding through a simple, mild and efficient procedure utilizing cellulose sulfuric acid (CSA) as a catalyst. The reaction work-up is very simple and catalyst can be easily separated from reaction mixture and reused several times in subsequent reactions.

Graphical abstractC5-unsubstituted 1,4-dihydropyridines were obtained in good to excellent yields by proceeding through a simple, mild and efficient procedure utilizing cellulose sulfuric acid (CSA) as a catalyst. The reaction work up is very simple and catalyst can be easily separated from reaction mixture and reused several times in subsequent reactions.Figure optionsDownload full-size imageDownload high-quality image (10 K)Download as PowerPoint slideResearch highlights▶ The natural biopolymers was used as solid support catalyst. ▶ Cellulose sulfuric acid catalyzed synthesis of 1,4-dihydropyridines. ▶ Suspension of catalyst in water was effective on yield of reaction. ▶ Catalyst can be easily separated and reused several times in subsequent reactions.