Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6659813 | The Journal of Chemical Thermodynamics | 2018 | 40 Pages |
Abstract
The effect of (Dâ)-fructose (fruit sugar), (D+)-galactose and (D+)-lactose (milk sugar) on the solute-solvent interactions occurred between the diphenhydramine-hydrochloride (DPH-HCl) drug and water was studied. To this end, the density, speed of sound and viscosity data for DPH-HCl drug in water and aqueous solutions of (Dâ)-fructose, (D+)-galactose and (D+)-lactose should have been measured. Thermodynamic properties such as the apparent molar volume (VÏ) and apparent molar isentropic compression (Ks,m) were calculated from the density and speed of sound values within sugar molality range of (0.05, 0.1, and 0.15)â¯molâ¯kgâ1 at Tâ¯=â¯(288.15, 293.15, 298.15, 308.15 and 318.15)â¯K. Extrapolation to the infinite dilution of VÏ and Ks,m values with using Redlich-Meyer equation was applied to find the corresponding limiting apparent molar quantities. Jones-Dole equation was used to obtain the viscosity B-coefficients. Interparticle interactions occurred between the DPH-HCl drug and water were determined by calculating the transfer parameters of limiting apparent molar volume and viscosity B-coefficient from DPH-HCl in water to the DPH-HCl in aqueous (Dâ)-fructose, (D+)-galactose and (D+)-lactose solutions.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Roghayeh Majdan-Cegincara, Mohammed Taghi Zafarani-Moattar, Hemayat Shekaari, Fariba Ghaffari,