Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6659823 | The Journal of Chemical Thermodynamics | 2018 | 36 Pages |
Abstract
Thermodynamic and spectroscopic properties of α-cyclodextrin and β-cyclodextrin in aqueous solution sulfathiazole have been investigated by volumetric, ultrasonic measurements at Tâ¯=â¯(288.15-308.15â¯K) along with absorption spectra and fluorescence studies. The apparent molar volumes at infinite dilution, VÏ0 and the apparent molar isentropic compression at infinite dilution KÏ,S0, have been calculated from density and speed of sound data. Furthermore, partial molar volumes of transfer, ÎtrVÏ0, partial molar isentropic compression of transfer, ÎtrKÏ,S0, apparent molar expansivity, EÏ0, Hepler's constant values, âEÏ0âTP and thermal expansion coefficient, α have also been evaluated to support the conclusions obtained from the volumetric and acoustic studies. These parameters are helpful to study the solvation behavior and various interactions present in the ternary solutions of (α-cyclodextrin/β-cyclodextrinâ¯+â¯sulfathiazoleâ¯+â¯water). Further, absorption and emission spectra has been recorded for aqueous sulfathiazole solution in α-cyclodextrin to analyze the host-guest interactions. The inclusion complex of sulfathiazole with α-cyclodextrin is investigated by UV-visible spectroscopy and fluorescence. The study indicates that sulpha drug forms 1:1 inclusion complexes with α-cyclodextrin.
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Authors
Amalendu Pal, Rekha Gaba, Surbhi Soni,