Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6661748 | Journal of Electroanalytical Chemistry | 2018 | 17 Pages |
Abstract
Nimesulide is an anti-inflammatory drug (NSAID) whose preferential selectivity for cyclooxygenase-2 (COX-2) leads to fewer adverse effects. Nimesulide acts on a single metabolic pathway of the arachidonic acid cascade. Recent studies show that multi-target NSAID is an important strategy for obtaining drugs fewer adverse effects. LQFM-091 has been proposed as a molecular hybridization from nimesulide and BF-389, with the aim to inhibit two enzymes involved in arachidonic acid metabolic cascade. The aim this work was the electrochemical characterization of LQFM-091. The electrochemical analyzes were conclusive to prove that the electroactive groups are unhindered and were important in this drug action mechanism.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Karla Carneiro de Siqueira Leite, Luane Ferreira Garcia, Germán Sanz, Flávio Colmati, Aparecido Ribeiro de Souza, Daniel da Costa Batista, Ricardo Menegatti, Eric de Souza Gil, Rafael Luque,