Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6662458 | Journal of Electroanalytical Chemistry | 2014 | 7 Pages |
Abstract
This work deals with simultaneous determination of hydrochlorothiazide (HCTZ) and valsartan (VAL) by square-wave voltammetry using a cathodically pretreated boron-doped diamond electrode. The method exhibits linear responses to HCTZ and VAL in the concentration range 1.97-88.1 μmol Lâ1 and 9.88-220 μmol Lâ1, respectively, in a Britton-Robinson buffer solution (pH 5.0), with detection limits of 0.639 μmol Lâ1 and 0.935 μmol Lâ1, respectively. The proposed method was successfully applied in the simultaneous determination of both antihypertensives in combined dosage forms and the results are in close agreement with those obtained using high performance liquid chromatography method.
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Authors
Ana Paula Pires Eisele, Guilherme Roberto Mansano, Fernanda Midori de Oliveira, Juliana Casarin, César Ricardo Teixeira Tarley, Elen Romão Sartori,