Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6663000 | Journal of Electroanalytical Chemistry | 2013 | 7 Pages |
Abstract
A three-dimensional (3-D) microfluidic-channel-based electrochemical DNA biosensor was constructed using anodic aluminum oxide (AAO) filtration membranes as the designing template by taking advantage of their well-defined cylindrical fluidic channels. Cyclic voltammetry (CV) measurements indicated that the microfluidic-channel-based DNA biosensor showed detection sensitivity amplified to 10â19Â M, which is one order of magnitude higher than attomolar (10â18Â M) range. Such enhanced detection sensitivity is attributed to the well-defined fluidic channel structure that gives high surface area for probe DNA immobilization and enables target DNA solutions to pass through its fluidic channels for rapid and efficient hybridization.
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Authors
Young Jo Kim, John E. Jones, Hao Li, Helen Yampara-Iquise, Guolu Zheng, Charles A. Carson, Michael Cooperstock, Michael Sherman, Qingsong Yu,