| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6668202 | Journal of Industrial and Engineering Chemistry | 2017 | 33 Pages |
Abstract
The purpose of the study was to develop caffeine-loaded gold nanoparticles (AuNPs) using a poly(lactic acid)-polyethylene glycol-poly(lactic acid) (PLA-PEG-PLA) polymer to enhance the anti-inflammatory activity of caffeine. Caffeine-loaded AuNPs were conjugated to PLA-PEG-PLA copolymer matrix via Ï-back bond between AuNPs and the ester carbonyl group of the polyester. The Ï-back bonded ester carbonyl oxygen strongly interacted with the caffeine molecule and exhibited enhanced anti-inflammatory activity. The physico-chemical characteristics of the resulting nanoconjugates were evaluated by a series of microscopic, diffraction, and spectroscopic methods. In vitro assays indicated increasing membrane stabilization of red blood cells and enhanced inhibition of protein denaturation.
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Authors
Kamalakannan Reena, Mani Gajendiran, Muthusamy Prabakaran, Susaimanickam Arul Antony, Kyobum Kim,