Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6669871 | Journal of Saudi Chemical Society | 2018 | 10 Pages |
Abstract
In an effort to develop novel antiamoebic scaffolds having better efficacy than the standard drug metronidazole (IC50 = 1.80 μM) used against Entamoeba histolytica, quinazolin-4(3H)-one Schiff base conjugates were synthesized and evaluated against HM1: IMSS strain of E. histolytica. Out of the thirteen compounds (S2-S14), six compounds (S2, S3, S4, S5, S6 and S11) were found to be better inhibitors than metronidazole and showed low cytotoxicity on HeLa cells, a cervical cancer cell line. The structure of intermediate compound S1 was confirmed by crystal structure studies.
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Authors
Saba Tariq, Fernando Avecilla, Guru Prasad Sharma, Neelima Mondal, Amir Azam,