Design and effective synthesis of novel furo[2,3-d]pyrimidine derivatives containing ethylene ether spacers

[1+4] Cycloaddition reaction of ethylene ether-based N,N-dimethybenzylidenebarbituric acid with alkyl isocyanide in DMF produced novel high substituted furo[2,3-d]pyrimidine derivatives containing ether spacers under mild reaction conditions. The structures of the products were deduced from their IR, 1H NMR, and 13C NMR spectroscopy. Good antibacterial activity was found in compound 5c.